Rapid whole-genome mutational profiling using next-generation sequencing technologies
نویسندگان
چکیده
منابع مشابه
Rapid whole-genome mutational profiling using next-generation sequencing technologies.
Forward genetic mutational studies, adaptive evolution, and phenotypic screening are powerful tools for creating new variant organisms with desirable traits. However, mutations generated in the process cannot be easily identified with traditional genetic tools. We show that new high-throughput, massively parallel sequencing technologies can completely and accurately characterize a mutant genome...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2008
ISSN: 1088-9051
DOI: 10.1101/gr.077776.108